Sure, here is a detailed and in-depth meaning and commentary on 1 Chronicles 5:21 from the King James Version of the Bible:

"21 And they took away their cattle; of their camels fifty thousand, and of sheep two hundred and fifty thousand, and of asses two thousand, and of men a hundred thousand."

The book of 1 Chronicles is a historical account of the nation of Israel, specifically focusing on the genealogies of the twelve tribes of Israel. This particular verse is part of a larger passage that describes the victory of the Reubenites, the Gadites, and the half-tribe of Manasseh over their enemies. In this context, the verse serves to highlight the power and success of the Israelites in battle.

The verse begins by stating, "And they took away their cattle," indicating that the victorious Israelites seized the livestock of their enemies as spoils of war. The specific numbers provided - fifty thousand camels, two hundred and fifty thousand sheep, two thousand donkeys, and a hundred thousand men - emphasize the magnitude of their victory. These large numbers indicate the wealth and abundance of the defeated enemies, and serve to underscore the strength and success of the Israelites in battle.

In a broader thematic sense, this verse emphasizes the concept of divine favor and blessing. The Israelites' victory in battle and their subsequent acquisition of vast wealth are presented as evidence of God's favor and support for His chosen people. Throughout the Bible, we see numerous instances of God's intervention in the lives of His people, providing them with strength, protection, and victory in the face of adversity. This theme of divine favor and blessing is a central tenet of the Judeo-Christian faith and is exemplified in this verse.

Furthermore, this verse also highlights the importance of obedience and faithfulness to God. The success of the Israelites in battle can be attributed to their unwavering commitment to following God's commands and trusting in His guidance. Throughout the Old Testament, we see that God rewards those who are obedient to His will and punishes those who stray from it. This verse serves as a powerful reminder of the importance of remaining faithful and obedient to God in all circumstances.

In terms of symbolism, the vast numbers of livestock and men mentioned in the verse symbolize the abundance and prosperity that comes from aligning oneself with God. The large quantities of camels, sheep, donkeys, and men represent the bountiful blessings that God bestows upon His people when they remain faithful to Him. Additionally, the livestock can be seen as symbols of wealth and abundance, further reinforcing the idea of God's provision and favor.

In conclusion, 1 Chronicles 5:21 is a powerful testament to the themes of divine favor, obedience, and abundance found throughout the Bible. The verse serves as a reminder of God's faithfulness to His people and the rewards that come from trusting in Him. It also underscores the importance of remaining obedient and faithful in order to receive the blessings and prosperity that God promises. Through its rich imagery and themes, this verse continues to inspire and encourage believers to this day.